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  • mean age at foll http

    2020-08-18

    mean age at follow-up 57.9 years)
    Responded to the long-term questionnaires n=146 (99 without previous breast cancer; 47 with previous breast cancer)
    Questionnaire responders that consented for medical records n=134 (91 without previous breast cancer; 43 with previous breast cancer)
    Non-responding women
    Deceased n=14
    Recurrence and metastasised breast cancer n=7
    Other cancers besides breast cancer, after risk-reducing mastectomy n=11
    Declined future participation n=14
    Non-responding women n=52 36 (26%) without previous breast cancer, mean age at follow-up 51.6 years;
    No questionnaire answers, but consent for medical records n=2 (1 without previous breast cancer; 1 with previous breast cancer)
    Fig. 1. Consort diagram, including details about written consent for clinical data collection from medical records.
    Table 1
    Demographic and clinical data of women that have undergone bilateral or contra-lateral risk-reducing surgery that have consented to extraction of clinical data from medical journals for the long-term follow-up study.
    Variable Cancera
    No cancer
    Number of women 44
    Age at risk-reducing surgery (year)
    Median 45
    Age at return of questionnaires (year)
    BRCA T16AinhA01 status
    BMI
    Bilateral prophylactic salpingo-oophorectomy
    Type of breast cancer
    None
    Type of breast cancer surgery prior risk-reducing surgery
    Breast conserving cancer surgery 20 (48)
    Type of risk-reducing surgery
    Mastectomy with immediate breast reconstruction 42 (95)
    Mastectomy without immediate breast reconstruction
    Reduction/mastopexy 1 (2)
    Radiotherapy
    Chemotherapy
    Endocrine therapy
    Reoperations (unforeseen) after risk-reducing breast surgeryc
    Missing
    a Women with previous breast cancer n ¼ 42, and gynaecological cancer n ¼ 2. b BRCAX ¼ women with breast cancer and/or ovarian cancer, screened negative for BRCA1 and BRCA2, and with family history of breast cancer. c Nipple reconstructions were not included.
    group's established database. The mean follow-up time from date of risk-reducing surgery was 11.5 (range 6.0e19.7) years. Limited information about the non-responders was available as we never obtained consent to extract data from their medical charts.
    3.1. Satisfaction with breast reconstruction (EORTC QLQ-BRR26)
    This questionnaire was used only at follow-up, thus not allowing for analysis over time. Women with previous breast cancer were generally more dissatisfied with the results of the surgery versus women without cancer, Table 2. Statistically significant group  differences were found in the adjusted analyses for the subscales ‘Disease treatment/surgery related symptoms’ (p ¼ 0.006), and ‘Sexuality’ (p ¼ 0.031), with lower levels of problems and higher satisfaction in the group without cancer. Concerning ‘Satisfaction with reconstructed nipple’, a oxytocin between-group difference was found in the unadjusted analyses (p ¼ 0.020) in the same direction. Clin-ical significant differences were noted for ‘Disease treatment/sur-gery related symptoms’ (S), ‘Sexuality’ (M), and ‘Satisfaction with reconstructed nipple’ (M). No other between-group differences were found.
    The long-term mean BIS summated scores (range 0e30) re-ported by women with and without previous breast cancer were 7.7 (SD 5.8) and 4.9 (SD 5.2), respectively. An unadjusted mean dif-ference was 2.8 (95% CI, 0.9 to 4.7). When adjusting for confounding factors, no statistical significant difference was found. Fig. 2 shows the proportions of women reporting any level of problem (1e3) for each item at the one-year and the follow-up assessments for both groups. There was a statistical significant improvement in self-consciousness at long-term versus the one-year assessment for women without cancer (p ¼ 0.026). No other statistically significant group differences, or differences at the long-term follow-up were observed for the body image items.
    At the long-term assessment, 20 (43%) women with and 57 (61%) without previous breast cancer reported a ‘current active sex-life’, versus 22 (63%) and 52 (76%) at the one-year assessment, respectively. A statistical significant increase in ‘Discomfort’ was found at the long-term assessment, versus one year post-RRM for women with previous breast cancer (p ¼ 0.016), see Table 3. Women without breast cancer showed a statistical significant in-crease in ‘Sexual habit’ over time (p ¼ 0.031). No statistical signifi-cant differences between the groups were observed at the long-term follow-up for ‘Pleasure’, ‘Discomfort’, or ‘Sexual habit’ after adjusting for confounding factors.